RESEARCH • DISCOVERY • INNOVATION

Engineering Biology. Advancing Discovery.

Our laboratory focuses on translational and functional genomics to understand how genetic alterations drive human disease. We combine CRISPR-based genome editing, in vivo cancer modeling, molecular biology, and genomic approaches to uncover the functional consequences of disease-associated genes and variants. Our research spans cancer biology and rare genetic disorders, with a particular interest in translating discoveries from genomic data into biological mechanisms and, ultimately, new opportunities for precision medicine.

Explore our research Meet the team

American University of Beirut
Case Western Reserve University
Est. 2025

What we study

Research themes

All research

Functional Genomics of Cancer

Which genes truly matter for cancer, and what happens when they work together?

CRISPR/Cas9, multiplexed genetics and in vivo models to find the genes that control tumor initiation, growth and progression.

Lung Cancer: From Early Events to Tumor Evolution

Cancer does not begin when a tumor becomes visible. The biological journey starts much earlier.

The earliest molecular and cellular events that push normal lung cells toward malignancy, and how they evolve over time.

Translational Genomics: From Bedside to Bench

Sometimes our most important research questions begin with a patient, not a petri dish.

Patient samples, clinical data and genomics brought back to the bench to find out what disease-associated alterations actually do.

Our approach

From a genomic clue to a biological story

We move beyond identifying genes and variants to experimentally uncovering what they do, combining CRISPR genome editing, in vivo models, molecular biology and genomics.

About the lab

CRISPR/Cas9 genome editing
Functional and multiplexed screens to find the genes that matter.
Molecular & cellular biology
Assays that turn variants into mechanisms.
Genomics & transcriptomics
Patient data and sequencing to guide the questions we ask.
In vivo disease models
Following tumors and disease in a living system.